Disclaimer:
The information provided in this article is for educational and informational purposes only and is not intended as medical advice. It should not be used to diagnose, treat, cure, or prevent any disease or health condition. Always consult with a qualified healthcare professional before starting any new treatment, including Ozone Therapy with UBI. The statements in this article have not been evaluated by the FDA.
Unlock the Benefits of Ozone Therapy with UBI: What Makes This IV Treatment Revolutionary
Let’s set the record straight—this isn’t a new therapy, and it’s certainly not experimental. While ozone therapy with Ultraviolet Blood Irradiation (UBI) has been practiced for nearly a century and embraced across Europe, the U.S. is just now catching on. As always, America seems to be playing catch-up in recognizing innovative and effective treatments.
Ozone therapy has been an important part of integrative medicine in Europe since the early 20th century, with its first medical applications dating back to World War I.1 Countries like Germany, Spain, and Italy have been at the forefront of incorporating these therapies into their healthcare systems, supported by ongoing clinical research. Germany allows ozone therapy to be practiced without restrictions, while Spain has regulated it in most regions. As of 2021, 23 public hospitals in Spain have adopted ozone therapy into their medical services. Italy has also made strides, with three out of 20 regions regulating the therapy. Notably, Greece was the first country worldwide to regularize ozone therapy in 1991. 2 Talk about being ahead of the curve!
At its core, UBI harnesses the power of light to activate biological processes that detoxify, reduce inflammation, and fight off pathogens. Pair it with ozone, and you’ve got a game-changing therapy that acts as a natural anti-inflammatory, anti-fungal, and anti-bacterial powerhouse. Together, they target chronic infections, autoimmune issues, cardiovascular conditions, and more.


How Does Ozone IV Therapy with UBI Work?
UBI takes a scientific approach by exposing your blood to high-energy light, enhancing the function of red and white blood cells. Each light wavelength has its own superpower:
- Red Light: Supports detoxification and stabilizes DNA.
- Amber Light: Improves blood flow and cellular communication.
- UV Light: Destroys pathogens and boosts immunity.
Ozone therapy complements UBI by increasing oxygen delivery, promoting antioxidant defenses, and turbocharging your immune response. In Europe, it’s often combined with IV vitamin therapy to maximize benefits, creating a comprehensive approach to wellness.
Why Europe Gets It:
Germany and Spain are shining examples of how ozone therapy is used effectively. Germans frequently pair it with UBI to tackle inflammation from conditions like rheumatoid arthritis. Spanish hospitals are using it to combat chronic infections, fatigue, and even as part of recovery plans for autoimmune disorders.
It doesn’t stop there—these therapies are being explored for their potential in chemotherapy-induced neuropathy, chronic fatigue syndrome, and cardiovascular health. Studies suggest that ozone improves circulation and oxygen use, which can help with conditions like peripheral artery disease. Imagine what it could do for someone struggling with poor circulation or chronic fatigue! 3, 4
Why Europe Uses Ozone, and Why we Offer it at iv&co
Enhancing Immune Function :
- Immune Modulation: IV ozone can help balance immune responses, making it potentially beneficial for autoimmune conditions like rheumatoid arthritis or lupus. 5
- Infections: It may support the body in fighting bacterial, viral, and fungal infections, including chronic Lyme disease, herpes, and Candida. 6
2 . Anti-Inflammatory Effects:
3 . Improved Circulation and Oxygen Utilization :
4 . Detoxification :
- Oxidative Stress Reduction: Ozone therapy stimulates the production of antioxidants, helping the body detoxify and reduce oxidative damage. 11
- Liver Support: It may assist in detoxifying the liver, making it useful for individuals exposed to environmental toxins or heavy metals.
5 . Chronic Fatigue and Energy Disorders :
- Fatigue Syndromes: Patients with chronic fatigue syndrome (CFS) or low energy often report feeling revitalized after ozone therapy due to its effects on oxygen utilization. 12
- Mitochondrial Support: Ozone can enhance mitochondrial function, the powerhouse of the cell, to improve energy production.
6 . Antimicrobial Effects :
9. Neurological and Cognitive Benefits :
10. Athletic Performance and Recovery :
- Endurance: Enhanced oxygen utilization can improve athletic performance and stamina.
- Recovery: Its anti-inflammatory and oxygenating effects support faster muscle recovery after exercise or injury. 21

Safety First
One of the reasons ozone therapy has thrived in Europe is its emphasis on safety. Clinics screen patients thoroughly—like testing for G6PD deficiency—to ensure they’re good candidates. Adverse effects are rare, but some patients may experience minor swelling at the injection site or a Herxheimer reaction (a temporary immune response as your body detoxifies).
Absolute Contraindications
It’s essential to understand who might not be a good candidate for ozone therapy with UBI. Below are the absolute contraindications:
Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency
Patients with this deficiency are at risk of hemolysis (red blood cell breakdown) when exposed to oxidative stress induced by ozone therapy.
Hyperthyroidism
Individuals with uncontrolled hyperthyroidism may experience exacerbated symptoms due to the stimulating effects of ozone on metabolism.
Severe Cardiovascular Instability
Conditions such as uncontrolled hypertension, severe arrhythmias, or recent myocardial infarction are contraindicated due to the potential circulatory demands imposed by ozone therapy.
Active Bleeding Disorders
Patients with coagulopathies or taking anticoagulant medications like warfarin may face an increased risk of bleeding.
Pregnancy
While research is limited, ozone therapy is typically avoided during pregnancy to ensure the safety of both mother and fetus.
Acute Alcohol Intoxication
Ozone therapy may exacerbate the effects of oxidative stress in individuals with alcohol-related toxicity.
Severe Anemia
Patients with very low hemoglobin levels may not tolerate blood extraction and re-infusion processes.
At iv&co, we’re dedicated to providing treatments that align with the latest global research while prioritizing your health and safety. If you’re ready to explore the benefits of ozone therapy with UBI, let’s start the conversation about how this incredible therapy can fit into your wellness journey.
Research Sources:
- AEPROMO. (n.d.). Ozonotherapy history. https://aepromo.org/en/ozonotherapy-history/
- AEPROMO. (n.d.). European Union member countries that have regulated ozone therapy. https://aepromo.org/en/european-union-member-countries-that-have-regulated-ozone-therapy/
- Bocci, V., Borrelli, E., Travagli, V., & Zanardi, I. (2023). The ozone paradox: Ozone is a strong oxidant as well as a medical drug. Medicinal Research Reviews, 43(1), 246-269. https://pmc.ncbi.nlm.nih.gov/articles/PMC9885089/
- Journal of Ozone Therapy. (n.d.). https://turia.uv.es/index.php/JO3T
- Martínez-Sánchez, G., Schwartz, A., & Di Donna, V. (2022). Potential cytoprotective activity of ozone therapy in SARS-CoV-2/COVID-19. Antioxidants, 11(5), 967. https://pubmed.ncbi.nlm.nih.gov/35531273/
- Scassellati, C., Galoforo, A. C., Bonvicini, C., Esposito, C., & Ricevuti, G. (2022). Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders. Frontiers in Microbiology, 13, 871645. https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.871645/full
- Scassellati, C., Ciani, M., Galoforo, A. C., Zanardini, R., Bonvicini, C., & Geroldi, C. (2020). Molecular mechanisms in cognitive frailty: potential therapeutic targets for oxygen-ozone treatment. Mechanisms of Ageing and Development, 186, 111210. https://pubmed.ncbi.nlm.nih.gov/30840304/
- Chirumbolo, S., & Bjørklund, G. (2022). The role of ozone in cancer prevention and therapy. Biomedicines, 10(3), 594. https://pmc.ncbi.nlm.nih.gov/articles/PMC8904924/
- Chirumbolo, S., & Bjørklund, G. (2023). Ozone therapy in cancer: A narrative review. Biomedicines, 11(8), 2246. https://pmc.ncbi.nlm.nih.gov/articles/PMC11515079/
- Franzini, M., Valdenassi, L., Ricevuti, G., Chirumbolo, S., Depfenhart, M., Bertossi, D., & Tirelli, U. (2024). Insights into the use of oxygen-ozone therapy in oncology. Medicine, 103(14), e35748. https://journals.lww.com/mgar/fulltext/2024/14040/insights_into_the_use_of_oxygen_ozone_therapy_in.2.aspx
- Chirumbolo, S., & Bjørklund, G. (2024). Ozone therapy in cancer: An update. Antioxidants, 13(2), 212. https://www.mdpi.com/2076-3921/13/2/212
- Tirelli, U., Cirrito, C., Pavanello, M., Piasentin, C., Lleshi, A., & Taibi, R. (2019). Ozone therapy in 65 patients with fibromyalgia: An effective therapy. Biomedical Journal of Scientific & Technical Research, 19(1), 14111-14114. https://biomedres.us/fulltexts/BJSTR.MS.ID.003602.php
- Smith, N. L., Wilson, A. L., Gandhi, J., Vatsia, S., & Khan, S. A. (2017). Ozone therapy: An overview of pharmacodynamics, current research, and clinical utility. Medical Gas Research, 7(3), 212-219. https://pmc.ncbi.nlm.nih.gov/articles/PMC6178636/
- Chirumbolo, S., Valdenassi, L., Simonetti, V., Bertossi, D., Ricevuti, G., & Franzini, M. (2022). Insights into the mechanisms of action of ozone in cancer: Therapeutic role. Scientific Reports, 12(1), 13636. https://www.nature.com/articles/s41598-022-17495-3
- Elvis, A. M., & Ekta, J. S. (2011). Ozone therapy: A clinical review. Journal of Natural Science, Biology, and Medicine, 2(1), 66-70. https://pmc.ncbi.nlm.nih.gov/articles/PMC5678031/
- Bocci, V. A., Zanardi, I., & Travagli, V. (2011). Ozone acting on human blood yields a hormetic dose-response relationship. Journal of Translational Medicine, 9, 66. https://www.scirp.org/journal/paperinformation?paperid=113644
- Franzini, M., Valdenassi, L., Ricevuti, G., Chirumbolo, S., Depfenhart, M., Bertossi, D., & Tirelli, U. (2023). High-dose ozone therapy in oncology patients: Efficacy, mechanisms and therapeutic potential. Genesis Publications. https://www.genesispub.org/high-dose-ozone-therapy-in-oncology-patients-efficacy-mechanisms-and-therapetic-potential
- Chirumbolo, S., & Bjørklund, G. (2023). Ozone therapy in cancer: A narrative review. Journal of Ozone Therapy, 7(1), e20231539. https://turia.uv.es/index.php/JO3T/article/view/15399
- Chirumbolo, S., & Bjørklund, G. (2023). Ozone therapy in cancer: A narrative review. Biomedicines, 11(8), 2246. https://pmc.ncbi.nlm.nih.gov/articles/PMC11355685/
- Chirumbolo, S., & Bjørklund, G. (2023). Ozone therapy in cancer: A narrative review. Biomedicines, 11(8), 2246. https://pmc.ncbi.nlm.nih.gov/articles/PMC11515058/
- Scassellati, C., Galoforo, A. C., Bonvicini, C., Esposito, C., & Ricevuti, G. (2022). Ozone: A natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders. Frontiers in Physiology, 13, 840623. https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.840623/full

Author: Jenny Haiar
Owner, Founder & CEO, iv&co, PLLC
About Jenny
Jenny is the visionary founder of iv&co, the first elective IV therapy business in the Dakotas, established over a decade ago. Her passion for wellness was ignited during her years as an OB ER nurse in Denver, Colorado, where she saw firsthand the power of hydration and recovery. Jenny is dedicated to bringing innovative, personalized health solutions to her community, helping clients achieve their wellness goals through IV therapy and beyond.







